Host range mutants of v-src: alterations in kinase activity and substrate interactions

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Host range mutants of v-src: alterations in kinase activity and substrate interactions.

Host range mutants of Schmidt-Ruppin v-src that transform chicken embryo fibroblasts (CEF) but not Rat-2 cells were generated previously by linker insertion-deletion mutagenesis (J. E. DeClue and G. S. Martin, J. Virol. 63:542-554, 1989). One of these mutants, SRX5, in which Tyr-416 is substituted by the sequence Ser Arg Asp, retained high levels of kinase activity in vitro and in vivo, both in...

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to a v-src Substrate and Is Located in

in cell-substratum contact sites. homologous to a v-src substrate and is located overexpressed in human carcinomas, is The product of the EMS1 gene, amplified and

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Control of src kinase activity by activators, inhibitors, and substrate chaperones.

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 1992

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.66.7.4315-4324.1992